do you know how opiates cause bradycardia and hypotension? Does exploit on opiate receptors play a role?
Opiods, given above the average doise, will cause the release of histamin, giving vasodilation (red skin and visceral reddishness too), and thus, decreasing the peripheral resistance, and producing a lowering contained by the mean pressure, and this is a divergent (not central) effect of opioids.
The "mu" receptors in the upper brainstem, will explanation some vagal stimulation (not as intense as it happens next to apomorphine, now once in a while used to provoke or induce vomiting by stimulation of the sigma receptors), but the vagus center in the floor of the IV ventricle (medulla oblongata) is stimulated, cause bradycardia, that can be partially reversed beside atropine, and completely, with the antagonist, naloxone or naltrexone ,
And as you can see, receptors play a push button roll on the effects of ANY opioid......
they relax smooth muscle
medicine and condition guarantee correctness , is for informational purposes only warning or treatment for any medical conditions.
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